While the medications found in the toxicological analysis may be prescribed in the United States for insomnia, anxiety, pain, or common cold symptoms (doxylamine), the vast majority of physicians in the US are extremely reluctant to prescribe multiple benzodiazepines (e.g., diazepam, alprazolam, and temazepam) to a single patient, let alone prescribe the same to a patient already taking a mix of oxycodone and hydrocodone. Although the Associated Press and other media reported that "police estimate Ledger's time of death between 1 pm and 2:45 pm " (on 22 January 2008),[87] the Medical Examiner's Office announced that it would not be publicly disclosing the official estimated time of death.[88][89] The official announcement of the cause and manner of Ledger's death heightened concerns about the growing problems of prescription drug abuse or misuse and combined drug intoxication (CDI).[9][86][90] 

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After sitting for early graduation exams at age 17, Ledger left school to pursue an acting career.[16] With Trevor DiCarlo, his best friend since he was three years old, Ledger drove across Australia from Perth to Sydney, returning to Perth to take a small role in Clowning Around (1992), the first part of a two-part television series, and to work on the TV series Sweat (1996), in which he played a gay cyclist.[13] From 1993 to 1997, Ledger also had parts in the Perth television series Ship to Shore (1993); in the short-lived Fox Broadcasting Company fantasy-drama Roar (1997); in Home and Away (1997), one of Australia's most successful television shows; and in the Australian film Blackrock (1997), his feature film debut.[13] In 1999, he starred in the teen comedy 10 Things I Hate About You and in the acclaimed Australian crime film Two Hands, directed by Gregor Jordan.[13]

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Heath Andrew Ledger[a] (4 April 1979 – 22 January 2008)[1] was an Australian actor and music video director. After performing roles in several Australian television and film productions during the 1990s, Ledger left for the United States in 1998 to further develop his film career. His work comprised nineteen films, including 10 Things I Hate About You (1999), The Patriot (2000), A Knight's Tale (2001), Monster's Ball (2001), Lords of Dogtown (2005), Brokeback Mountain (2005), The Brothers Grimm (2005), Casanova (2005), The Dark Knight (2008), and The Imaginarium of Doctor Parnassus (2009), the latter two being posthumous releases.[2] He also produced and directed music videos and aspired to be a film director.[3]

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Two weeks later on 6 February 2008, the Office of the Chief Medical Examiner of New York released its conclusions, based on an initial autopsy on 23 January 2008 and a subsequent complete toxicological analysis.[8][85][86] The report concludes, in part, "Mr. Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam and doxylamine." It states definitively: "We have concluded that the manner of death is accident, resulting from the abuse of prescribed medications."[8][10]

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He was working with Scottish screenwriter and producer Allan Scott on an adaptation of the 1983 novel The Queen's Gambit by Walter Tevis, which would have been his first feature film as a director. He also intended to act in the film, with Canadian actress Ellen Page proposed in the lead role.[3][47][48] Ledger's final directorial work, in which he shot two music videos before his death, premiered in 2009.[49] The music videos, completed for Modest Mouse and Grace Woodroofe,[50] include an animated feature for Modest Mouse's song, "King Rat", and the Woodroofe video for her cover of David Bowie's "Quicksand".[51] The "King Rat" video premiered on 4 August 2009.[52]
Eleven months after Ledger's death, on 23 December 2008, Jake Coyle, writing for the Associated Press, announced that "Heath Ledger's death was voted 2008's top entertainment story by U.S. newspaper and broadcast editors surveyed by The Associated Press". He claimed that this was partially a result of the "shock and confusion" surrounding the circumstances of Ledger's death, as well as due to Ledger's "legacy [...] in a roundly acclaimed performance as the Joker in the year's biggest box office hit The Dark Knight".[102]

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