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The "HKLM\SOFTWARE" subkey contains software and Windows settings (in the default hardware profile). It is mostly modified by application and system installers. It is organized by software vendor (with a subkey for each), but also contains a "Windows" subkey for some settings of the Windows user interface, a "Classes" subkey containing all registered associations from file extensions, MIME types, Object Classes IDs and interfaces IDs (for OLE, COM/DCOM and ActiveX), to the installed applications or DLLs that may be handling these types on the local machine (however these associations are configurable for each user, see below), and a "Policies" subkey (also organized by vendor) for enforcing general usage policies on applications and system services (including the central certificates store used for authenticating, authorizing or disallowing remote systems or services running outside the local network domain).
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Registry values are name/data pairs stored within keys. Registry values are referenced separately from registry keys. Each registry value stored in a registry key has a unique name whose letter case is not significant. The Windows API functions that query and manipulate registry values take value names separately from the key path and/or handle that identifies the parent key. Registry values may contain backslashes in their names, but doing so makes them difficult to distinguish from their key paths when using some legacy Windows Registry API functions (whose usage is deprecated in Win32).
Prior to the introduction of registration-free COM, developers were encouraged to add initialization code to in-process and out-of-process binaries to perform the registry configuration required for that object to work. For in-process binaries such as .DLL and .OCX files, the modules typically exported a function called DllInstall() that could be called by installation programs or invoked manually with utilities like Regsvr32.exe; out-of-process binaries typically support the commandline arguments /Regserver and /Unregserver that created or deleted the required registry settings. COM applications that break because of DLL Hell issues can commonly be repaired with RegSvr32.exe or the /RegServer switch without having to re-invoke installation programs.