In Windows, use of the registry for storing program data is a matter of developer's discretion. Microsoft provides programming interfaces for storing data in XML files (via MSXML) or database files (via SQL Server Compact) which developers can use instead. Developers are also free to use non-Microsoft alternatives or develop their own proprietary data stores.

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Special ACEs on the security descriptor can also implement mandatory integrity control for the registry key and subkeys. A process running at a lower integrity level cannot write, change or delete a registry key/value, even if the account of the process has otherwise been granted access through the ACL. For instance, Internet Explorer running in Protected Mode can read medium and low integrity registry keys/values of the currently logged on user, but it can only modify low integrity keys.[37]
Also like the file system, PowerShell uses the concept of a current location which defines the context on which commands by default operate. The Get-ChildItem (also available through the alias ls or dir) retrieves the child keys of the current location. By using the Set-Location (or the alias cd) command the user can change the current location to another key of the registry. Commands which rename items, remove items, create new items or set content of items or properties can be used to rename keys, remove keys or entire sub-trees or change values.

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