The "HKLM\SOFTWARE" subkey contains software and Windows settings (in the default hardware profile). It is mostly modified by application and system installers. It is organized by software vendor (with a subkey for each), but also contains a "Windows" subkey for some settings of the Windows user interface, a "Classes" subkey containing all registered associations from file extensions, MIME types, Object Classes IDs and interfaces IDs (for OLE, COM/DCOM and ActiveX), to the installed applications or DLLs that may be handling these types on the local machine (however these associations are configurable for each user, see below), and a "Policies" subkey (also organized by vendor) for enforcing general usage policies on applications and system services (including the central certificates store used for authenticating, authorizing or disallowing remote systems or services running outside the local network domain).
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In Windows, use of the registry for storing program data is a matter of developer's discretion. Microsoft provides programming interfaces for storing data in XML files (via MSXML) or database files (via SQL Server Compact) which developers can use instead. Developers are also free to use non-Microsoft alternatives or develop their own proprietary data stores.
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