Like other files and services in Windows, all registry keys may be restricted by access control lists (ACLs), depending on user privileges, or on security tokens acquired by applications, or on system security policies enforced by the system (these restrictions may be predefined by the system itself, and configured by local system administrators or by domain administrators). Different users, programs, services or remote systems may only see some parts of the hierarchy or distinct hierarchies from the same root keys.

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The "HKLM\SYSTEM" key is normally only writable by users with administrative privileges on the local system. It contains information about the Windows system setup, data for the secure random number generator (RNG), the list of currently mounted devices containing a filesystem, several numbered "HKLM\SYSTEM\Control Sets" containing alternative configurations for system hardware drivers and services running on the local system (including the currently used one and a backup), a "HKLM\SYSTEM\Select" subkey containing the status of these Control Sets, and a "HKLM\SYSTEM\CurrentControlSet" which is dynamically linked at boot time to the Control Set which is currently used on the local system. Each configured Control Set contains:
Individual settings for users on a system are stored in a hive (disk file) per user. During user login, the system loads the user hive under the HKEY_USERS key and sets the HKCU (HKEY_CURRENT_USER) symbolic reference to point to the current user. This allows applications to store/retrieve settings for the current user implicitly under the HKCU key.

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