The hierarchy of registry keys can only be accessed from a known root key handle (which is anonymous but whose effective value is a constant numeric handle) that is mapped to the content of a registry key preloaded by the kernel from a stored "hive", or to the content of a subkey within another root key, or mapped to a registered service or DLL that provides access to its contained subkeys and values.
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In Windows, use of the registry for storing program data is a matter of developer's discretion. Microsoft provides programming interfaces for storing data in XML files (via MSXML) or database files (via SQL Server Compact) which developers can use instead. Developers are also free to use non-Microsoft alternatives or develop their own proprietary data stores.